Afterlife begins with Karen Hill, who has suffered from a congenital heart condition, is taken from her family. Karen has a husband (Bert) and two kids, a girl (Melody) and a boy (Roy). The story now divides into two major themes: one on Earth with Karen’s family struggling in life, and the other in Paradise with Karen. Each of Karen’s family members suffers in their own distinct ways and successful outcomes look to be quite impossible. Karen is given a buddy and an angel to help her negotiate Paradise, and she’s given a quest by God that she and her cohort must complete. Is there any way even God can bring about good from the awesome calamities and suffering about to befall her loved ones?